2. Signaling Pathways
  3. GPCR/G Protein
  4. Melanopsin Receptor

Melanopsin Receptor

OPN4

 

Melanopsin Receptor Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125145
    AA92593
    		Antagonist 99.94%
    AA92593 is a selective and competitive melanopsin OPN4 antagonist.
    AA92593
  • HY-124157
    AA41612
    		Antagonist 99.78%
    AA41612 is a melanopsin (Opn4) inhibitor with an IC50 of 15.8 nM, a Ki of 0.43 nM, and a Kd of 0.28 nM. AA41612 competes with retinal for binding to melanopsin, blocks melanopsin activation, and inhibits melanopsin-mediated phototransduction processes without affecting rod- and cone-mediated responses. AA41612 attenuates light-induced melanopsin photocurrents, reduces light-induced cytoplasmic calcium elevation, and weakens high-irradiance pupillary light reflex in mice with induced classical photoreceptor degeneration. AA41612 can be used in studies related to migraine and photophobia.
    AA41612